Publications

 

Selected publications

  • Yang S*, Cui YH*, Li H*, Wei J*, Park G, Sun M, Veghese M, Wilkinson E, Nam T, Lungstrom L, Cui X, Ryu T, Chen J, Bissonnette M, He C, He YY. YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis. Nat. Commun. 16 (2025) 9946. (* Co-first author). View in: Nature Communications
  • Wilkinson E*, Cui YH*, Yang Z, Verghese M, Yang S, Sun M, Zhu H, Peterson J, Zhao Y, Chen M, He C, and He YY. Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity. Cell Rep., 44 (2025) 116311. (* Co-first author). View in: PubMed
  • Freya Q. Zhang, Jiacheng Li, Rukang Zhang, Jiayi Tu, Zhicheng Xie, Takemasa Tsuji, Hardik Shah, Matthew O. Ross, Ruitu Lyu, Junko Matsuzaki, Kelly Xue, Fatima Choudry, Chunzhao Yin, Hamed R. Youshanlouei, Syed Shah, Michael W. Drazer, Yu-Ying He, B Marc Bissonnette, Yuancheng Li, Hui Mao, Jun Huang, Lei Dong, Rui Su, Chuan He, Kunle Odunsi, Jing Chen, and Hao Fan. Zeaxanthin augments CD8+ effector T cell function by enhancing TCR stimulation. Cell Rep. Med., 6 (2025) 102324. View in: PubMed
  • Li H, Wilkinson E, Cui YH, Lu K, Yang S, Bissonnette M, He YY. SSB regulates METTL16-mediated RNA m6A methylation and colorectal tumor growth. Cell Rep., 44 (2025) 115926. PMID: 40580478. PMCID: PMC12336999. View in: PubMed
  • Cui YH, Wei J, Fan H, Li W, Zhao L, Wilkinson E, Peterson J, Xie L, Zou Z, Yang S, Applebaum MA, Kline J, Chen J, He C, He YY. Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity. Proc. Natl. Acad. Sci. USA, 121 (2024) e2407910121. PMCID: PMC11665913. View in: PubMed
  • Yang, Z*, Verghese M*, Yang, S, He YY. The m6A reader YTHDC2 regulates UVB-induced DNA Damage Repair and histone modification. Photochem. Photobiol. 100 (2023) 1031-40. (* Co-first author). PMCID: PMC11228125. View in: PubMed
  • Fan H, Xia S, Gao X, Xiang J, Li Y, Ross MO, Lim SA, Xie L, Zhang F, Zheng Z, Zhang R, Wu R, Tu J, Dong L, Su R, Chen X, Althaus T, Riedell P, Jonker P, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel A, Opferman J, Tsuji T, Matsuzaki J, Faubert B, Elf SE, Bissonnette M, He YY, Kline J, Mao H, Odunsi K, Chi H, He C, and Chen J. Trans-vaccenic acid reprograms CD8+ T cells and anti-tumor immunity. Nature, 623 (2023) 1034-43. PMCID: PMC10686835. View in: PubMed
  • Lyu R, Tong W, Park G, He YY, Chen M, He C. KAS-Analyzer: a novel computational framework for exploring KAS-seq data. Bioinformatics Advances, In press, 3 (2023), vbad121. PMCID: PMC10516523. View in: PubMed
  • Lazaroff J, Duan GY, Verghese M, Bertacchi, B, Yang S, He YY, Bolotin D. A prospective Cohort Study Evaluating m6A RNA Methylation in Cutaneous Squamous Cell Carcinoma. J. Am. Acad. Dermatol. 89 (2023)1083-4. PMID: 37516358. View in: PubMed
  • Yang, Z*, Wilkinson E*, Cui YH*, Li HX, He YY. NAT10 regulates the repair of UV-induced DNA damage and tumorigenicity. Toxicol. Appl. Pharmacol. 477 (2023) 116688. (* Co-first author). PMCID: PMC10591715. View in: PubMed
  • Park G, Cui YH, Yang S, Sun M, Wilkinson E, Li H, Zhang Y, Chen J, Bissonnette M, Lin W, He YY. Moderate low UVB irradiation modulates tumor-associated macrophages and dendritic cells and promotes anti-tumor immunity in tumor-bearing mice. Photochem. Photobiol. 99 (2023) 850-856. PMCID: PMC9884319. View in: PubMed
  • Cui YH, Wilkinson E, Peterson J, He YY. ALKBH4 stabilization is required for arsenic-induced 6mA DNA methylation inhibition, keratinocyte malignant transformation, and tumorigenicity. Water, 14 (2022) 3595. PMC10194016. View in: PubMed
  • Zhang R, Zhang F, Tu J, Gao X, Wu R, Fan H, Chen D, Qu CK, Zheng H, Elf S, Faubert B, Wang M, Deberardinis R, He YY, Bissonnette M, Chen J. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells. Cell Chem. Biol. 29 (2022) 1200-1208.e6. View in: PubMed
  • Gao X, Liu Y, Li Y, Fan H, Wu R, Zhang R, Faubert B, He YY, Bissonnette MB, Xia S, Chen D, Mao H, Boggon TJ, Chen J. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. Mol. Cell, 82 (2022) 1992-2005. View in: PubMed
  • Wei J, Yu X, Cui X, Liu J, Yang L, Gao, B, He PC, Zhang L Dong X, Hao Z; Wang H; Dou X, Sepich C, He YY, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse tissues. Science, 376 (2022) 968-973. PMC9746489. View in: PubMed
  • Yang Z*, Yang S*, Cui YH*, Wei J*, Shah P, Cui X, He C, He YY. METTL14 regulates global genome repair and tumorigenesis and is degraded by selective autophagy. Proc. Natl. Acad. Sci. USA, 118 (2021) e2025948118. (* Co-first author). PMCID: PMC8536359. View in: PubMed
  • Cui YH*, Yang S*, Wei J*, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY. Autophagy of the m6A mRNA demethylase FTO is impaired by low arsenic exposure to promote tumorigenesis. Nat. Commun. 12 (2021) 2183. (* Co-first author). DOI: 10.1038/s41467-021-22469-6. PMCID: PMC8041927. (Selected as an NIEHS Extramural Paper of the Month: https://factor.niehs.nih.gov/2021/7/papers/dert/index.htm). View in: PubMed
  • Qiang L*, Yang S*, Cui YH, and He YY. Epidermal autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing. Autophagy, 17 (2021) 2128-2143. (* Co-first author). PMCID: PMC8496719. View in: PubMed
  • Yang S*, Wei J*, Cui YH*, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 06 25; 10(1):2782. (* Co-first author). View in: PubMed
  • Shah P, Zhao B, Qiang L, He YY. Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Nucleic Acids Res. 2018 06 01; 46(10):5050-5060. View in: PubMed
  • Qiang L, Sample A, Liu H, Wu X, He YY. Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Sci Rep. 2017 10 26; 7(1):14110. View in: PubMed
  • Qiang L, Sample A, Shea CR, Soltani K, Macleod KF, He YY. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy. 2017; 13(12):2086-2103. View in: PubMed
  • Sample A, Zhao B, Qiang L, He YY. Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J Biol Chem. 2017 09 08; 292(36):14786-14795. View in: PubMed
  • Yang S, Qiang L, Sample A, Shah P, He YY. NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance. J Biol Chem. 2017 02 24; 292(8):3379-3388. View in: PubMed
  • Qiang L, Zhao B, Shah P, Sample A, Yang S, He YY. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy. 2016; 12(2):357-68. View in: PubMed
  • Chastkofsky MI, Bie W, Ball-Kell SM, He YY, Tyner AL. Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin. J Invest Dermatol. 2015 Oct; 135(10):2492-2501. View in: PubMed
  • Ming M, Zhao B, Shea CR, Shah P, Qiang L, White SR, Sims DM, He YY. Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol. 2015 Apr; 135(4):936-45.e4. View in: PubMed
  • Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A, Sims DM, He YY. Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells. J Biol Chem. 2014 Dec 26; 289(52):35806-14. View in: PubMed
  • Ming M, Han W, Zhao B, Sundaresan NR, Deng CX, Gupta MP, He YY. SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res. 2014 Oct 15; 74(20):5925-33. View in: PubMed
  • Qiang L, Wu C, Ming M, Viollet B, He YY. Autophagy controls p38 activation to promote cell survival under genotoxic stress. J Biol Chem. 2013 Jan 18; 288(3):1603-11. View in: PubMed
  • Han W, Soltani K, Ming M, He YY. Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis. Cancer Prev Res (Phila). 2012 Sep; 5(9):1155-62. View in: PubMed
  • Han W, Ming M, Zhao R, Pi J, Wu C, He YY. Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis. J Biol Chem. 2012 May 25; 287(22):18788-95. View in: PubMed
  • Ming M, Feng L, Shea CR, Soltani K, Zhao B, Han W, Smart RC, Trempus CS, He YY. PTEN positively regulates UVB-induced DNA damage repair. Cancer Res. 2011 Aug 01; 71(15):5287-95. View in: PubMed
  • Han W, Ming M, He YY. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem. 2011 Jul 01; 286(26):22825-32. View in: PubMed
  • Ming M, Shea CR, Feng L, Soltani K, He YY. UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation. J Invest Dermatol. 2011 Jul; 131(7):1583-6. View in: PubMed
  • Thompson EA, Zhu S, Hall JR, House JS, Ranjan R, Burr JA, He YY, Owens DM, Smart RC. C/EBPa expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPa confers susceptibility to UVB-induced skin squamous cell carcinomas. J Invest Dermatol. 2011 Jun; 131(6):1339-46. View in: PubMed
  • Ming M, Shea CR, Guo X, Li X, Soltani K, Han W, He YY. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22623-8. View in: PubMed
  • Han W, Ming M, He TC, He YY. Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis. J Biol Chem. 2010 Apr 09; 285(15):11369-77. View in: PubMed

 

All lab publications